Notch activation inhibits AML growth and survival: a potential therapeutic approach

Although aberrant Notch activation contributes to leukemogenesis in T cells, its role in acute myelogenous leukemia (AML) remains unclear. Here, we report that human AML samples have robust expression of Notch receptors; however, Notch receptor activation and expression of downstream Notch targets a...

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Detalhes bibliográficos
Main Authors: Kannan, Sankaranarayanan, Sutphin, Robert M., Hall, Mandy G., Golfman, Leonard S., Fang, Wendy, Nolo, Riitta M., Akers, Lauren J., Hammitt, Richard A., McMurray, John S., Kornblau, Steven M., Melnick, Ari M., Figueroa, Maria E., Zweidler-McKay, Patrick A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570106/
https://ncbi.nlm.nih.gov/pubmed/23359069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121527
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