Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression

Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T-cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target...

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Detalhes bibliográficos
Main Authors: Kannan, Sankaranarayanan, Fang, Wendy, Song, Guangchun, Mullighan, Charles G., Hammitt, Richard, McMurray, John, Zweidler-McKay, Patrick A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062299/
https://ncbi.nlm.nih.gov/pubmed/21224467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-253419
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