Anti-Leukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia

In B cell acute lymphoblastic leukemia (B-ALL), activation of Notch signaling leads to cell-cycle arrest and apoptosis. We aimed to harness knowledge acquired by understanding a mechanism of Notch-induced cell death to elucidate a therapeutically viable target in B-ALL. To this end, we identified th...

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Gepubliceerd in:Mol Cancer Ther
Hoofdauteurs: Kannan, Sankaranarayanan, Aitken, Marisa J. L., Herbrich, Shelley M., Golfman, Leonard S., Hall, Mandy G., Mak, Duncan H, Burks, Jared K, Song, Guangchun, Konopleva, Marina, Mullighan, Charles G., Chandra, Joya, Zweidler-McKay, Patrick A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726528/
https://ncbi.nlm.nih.gov/pubmed/31227645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0706
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