Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia

The Notch pathway can have both oncogenic and tumor suppressor roles, depending on cell context. For example, Notch signaling promotes T cell differentiation and is leukemogenic in T cells, whereas it inhibits early B cell differentiation and acts as a tumor suppressor in B cell leukemia where it in...

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Autori principali: Kuang, Shao-Qing, Fang, Zhihong, Zweidler-McKay, Patrick A., Yang, Hui, Wei, Yue, Gonzalez-Cervantes, Emilio A., Boumber, Yanis, Garcia-Manero, Guillermo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637323/
https://ncbi.nlm.nih.gov/pubmed/23637910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061807
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