Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia

Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes were methy...

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Detalhes bibliográficos
Main Authors: Vilas–Zornoza, Amaia, Agirre, Xabier, Martín-Palanco, Vanesa, Martín-Subero, José Ignacio, San José-Eneriz, Edurne, Garate, Leire, Álvarez, Sara, Miranda, Estíbaliz, Rodríguez-Otero, Paula, Rifón, José, Torres, Antonio, Calasanz, María José, Cigudosa, Juan Cruz, Román-Gómez, José, Prósper, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046174/
https://ncbi.nlm.nih.gov/pubmed/21386967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017012
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