Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome

The combination of defined factors with small molecules targeting epigenetic factors is a strategy that has been shown to enhance optimal derivation of iPSCs and could be used for disease modelling, high throughput screenings and/or regenerative medicine applications. In this study, we showed that a...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Rodriguez-Madoz, Juan Roberto, San Jose-Eneriz, Edurne, Rabal, Obdulia, Zapata-Linares, Natalia, Miranda, Estibaliz, Rodriguez, Saray, Porciuncula, Angelo, Vilas-Zornoza, Amaia, Garate, Leire, Segura, Victor, Guruceaga, Elizabeth, Agirre, Xabier, Oyarzabal, Julen, Prosper, Felipe
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744984/
https://ncbi.nlm.nih.gov/pubmed/29281720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190275
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