Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia

Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes were methy...

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Autors principals: Vilas–Zornoza, Amaia, Agirre, Xabier, Martín-Palanco, Vanesa, Martín-Subero, José Ignacio, San José-Eneriz, Edurne, Garate, Leire, Álvarez, Sara, Miranda, Estíbaliz, Rodríguez-Otero, Paula, Rifón, José, Torres, Antonio, Calasanz, María José, Cigudosa, Juan Cruz, Román-Gómez, José, Prósper, Felipe
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046174/
https://ncbi.nlm.nih.gov/pubmed/21386967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017012
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