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Phenyl Ring-Substituted Lobelane Analogs: Inhibition of [(3)H]Dopamine Uptake at the Vesicular Monoamine Transporter-2
Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). To increase selectivity for VMAT2, chemically defunctionalized lobeline analogs, including lobelane, were designed to eliminate nicotinic acetylcholine receptor affinity. The...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3061534/ https://ncbi.nlm.nih.gov/pubmed/20876747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172882 |
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