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Phenyl Ring-Substituted Lobelane Analogs: Inhibition of [(3)H]Dopamine Uptake at the Vesicular Monoamine Transporter-2

Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). To increase selectivity for VMAT2, chemically defunctionalized lobeline analogs, including lobelane, were designed to eliminate nicotinic acetylcholine receptor affinity. The...

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Hlavní autoři: Nickell, Justin R., Zheng, Guangrong, Deaciuc, Agripina G., Crooks, Peter A., Dwoskin, Linda P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061534/
https://ncbi.nlm.nih.gov/pubmed/20876747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172882
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