Phenyl Ring-Substituted Lobelane Analogs: Inhibition of [(3)H]Dopamine Uptake at the Vesicular Monoamine Transporter-2

Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). To increase selectivity for VMAT2, chemically defunctionalized lobeline analogs, including lobelane, were designed to eliminate nicotinic acetylcholine receptor affinity. The...

Full description

Saved in:
Bibliographic Details
Main Authors: Nickell, Justin R., Zheng, Guangrong, Deaciuc, Agripina G., Crooks, Peter A., Dwoskin, Linda P.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061534/
https://ncbi.nlm.nih.gov/pubmed/20876747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172882
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items