meso-Transdiene Analogs Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-Evoked Dopamine Release

Lobeline, a nicotinic receptor antagonist and neurotransmitter transporter inhibitor, is a candidate pharmacotherapy for methamphetamine abuse. meso-Transdiene (MTD), a lobeline analog, lacks nicotinic receptor affinity, retains affinity for vesicular monoamine transporter 2 (VMAT2), and, surprising...

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Autors principals: Horton, David B., Siripurapu, Kiran B., Norrholm, Seth D., Culver, John P., Hojahmat, Marhaba, Beckmann, Joshua S., Harrod, Steven B., Deaciuc, Agripina G., Bardo, Michael T., Crooks, Peter A., Dwoskin, Linda P.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2011
Matèries:
Neuropharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061531/
https://ncbi.nlm.nih.gov/pubmed/21177475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175117
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