meso-Transdiene Analogs Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-Evoked Dopamine Release

Lobeline, a nicotinic receptor antagonist and neurotransmitter transporter inhibitor, is a candidate pharmacotherapy for methamphetamine abuse. meso-Transdiene (MTD), a lobeline analog, lacks nicotinic receptor affinity, retains affinity for vesicular monoamine transporter 2 (VMAT2), and, surprising...

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Autori principali: Horton, David B., Siripurapu, Kiran B., Norrholm, Seth D., Culver, John P., Hojahmat, Marhaba, Beckmann, Joshua S., Harrod, Steven B., Deaciuc, Agripina G., Bardo, Michael T., Crooks, Peter A., Dwoskin, Linda P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2011
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061531/
https://ncbi.nlm.nih.gov/pubmed/21177475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175117
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