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Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent

PURPOSE: SR13668, a bis-indole with potent activity in vitro and in vivo against various cancers and promising cancer chemopreventive activity, was found to have very low oral bioavailability, <1%, in rats during pilot pharmacokinetic studies. The objective of these studies was to better understa...

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Hlavní autoři: Green, Carol E., Swezey, Robert, Bakke, James, Shinn, Walter, Furimsky, Anna, Bejugam, Naveen, Shankar, Gita N., Jong, Ling, Kapetanovic, Izet M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061244/
https://ncbi.nlm.nih.gov/pubmed/20623225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1395-9
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