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Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability

2-Chloro-5-nitro-N-phenyl-benzamide (GW9662), a potent irreversible PPAR-γ antagonist, has shown promise as a cancer chemopreventive agent and is undergoing preclinical evaluations. Studies were initiated to assess its bacterial mutagenicity and pharmacokinetic profile in two animal species prior to...

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Detalhes bibliográficos
Main Authors: Kapetanovic, Izet M., Lyubimov, Alexander V., Kabirova, Elena V., Kabirov, Kasim K., Rasay, Laura, Swezey, Robert, Green, Carol, Kopelovich, Levy
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357543/
https://ncbi.nlm.nih.gov/pubmed/22450444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.03.002
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