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The p53 Inhibitor MDM2 Facilitates Sonic Hedgehog-Mediated Tumorigenesis and Influences Cerebellar Foliation

Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor. The Sonic Hedgehog (Shh) pathway is important for GNP proliferation; however, the factors regulating the exten...

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Detalhes bibliográficos
Main Authors: Malek, Reem, Matta, Jennifer, Taylor, Natalie, Perry, Mary Ellen, Mendrysa, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060880/
https://ncbi.nlm.nih.gov/pubmed/21437245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017884
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