The p53 Inhibitor MDM2 Facilitates Sonic Hedgehog-Mediated Tumorigenesis and Influences Cerebellar Foliation

Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor. The Sonic Hedgehog (Shh) pathway is important for GNP proliferation; however, the factors regulating the exten...

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Bibliographic Details
Main Authors: Malek, Reem, Matta, Jennifer, Taylor, Natalie, Perry, Mary Ellen, Mendrysa, Susan M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060880/
https://ncbi.nlm.nih.gov/pubmed/21437245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017884
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