Sonic Hedgehog Signaling in Cerebellar Development and Cancer

The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often causes neurodevelopmental diseases and brain tumors. In the cerebellum, SHH secreted by Purkinje cells is a potent mitogen for granule cell pro...

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Detalhes bibliográficos
Main Authors: Wanchen Wang, Ryo Shiraishi, Daisuke Kawauchi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
sonic hedgehog
cerebellum
medulloblastoma
brain tumor
patched1
smoothened
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2022.864035/full
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