Regulation of CCN2/CTGF Expression in the Nucleus Pulposus of the Intervertebral Disc: Role of Smad and AP1 Signaling

OBJECTIVE: To investigate TGFβ regulation of CTGF expression in cells of the nucleus pulposus. METHODS: Real Time RT-PCR and Western blot analysis was used to measure CTGF expression in the nucleus pulposus. Transfections were used to measure the effect of Smad2/3/7 and AP1on TGFβ mediated CTGF prom...

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Main Authors: Tran, Cassie M., Markova, Dessislava, Smith, Harvey E., Susarla, Bala, Ponnappan, Ravi Kumar, Anderson, D Greg, Symes, Aviva, Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060556/
https://ncbi.nlm.nih.gov/pubmed/20222112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27445
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