CCN2 Suppresses Catabolic Effects of Interleukin-1β through α5β1 and αVβ3 Integrins in Nucleus Pulposus Cells: IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION

The objective of the study was to examine the regulation of CCN2 by inflammatory cytokines, IL-1β, and TNF-α and to determine whether CCN2 modulates IL-1β-dependent catabolic gene expression in nucleus pulposus (NP) cells. IL-1β and TNF-α suppress CCN2 mRNA and protein expression in an NF-κB-depende...

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Detalhes bibliográficos
Main Authors: Tran, Cassie M., Schoepflin, Zachary R., Markova, Dessislava Z., Kepler, Christopher K., Anderson, D. Greg, Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953253/
https://ncbi.nlm.nih.gov/pubmed/24464580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526111
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