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Hypoxia-inducible Factor (HIF)-1α and CCN2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells: CCN2 SUPPRESSES HIF-1α LEVEL AND TRANSCRIPTIONAL ACTIVITY
The objective of the study was to investigate if hypoxia-inducible factor (HIF)-1α and connective tissue growth factor (CCN2) form a regulatory network in hypoxic nucleus pulposus (NP) cells. A decrease in CCN2 expression and proximal promoter activity was observed in NP cells after hypoxic culture....
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3642312/ https://ncbi.nlm.nih.gov/pubmed/23530034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448860 |
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