Hypoxia-inducible Factor (HIF)-1α and CCN2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells: CCN2 SUPPRESSES HIF-1α LEVEL AND TRANSCRIPTIONAL ACTIVITY

The objective of the study was to investigate if hypoxia-inducible factor (HIF)-1α and connective tissue growth factor (CCN2) form a regulatory network in hypoxic nucleus pulposus (NP) cells. A decrease in CCN2 expression and proximal promoter activity was observed in NP cells after hypoxic culture....

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Detalhes bibliográficos
Main Authors: Tran, Cassie M., Fujita, Nobuyuki, Huang, Bau-Lin, Ong, Jessica R., Lyons, Karen M., Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642312/
https://ncbi.nlm.nih.gov/pubmed/23530034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448860
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