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TonEBP and HIF Coordinate Hsp70 Expression in Hypoxic Nucleus Pulposus Cells: Role of Hsp70 in HIF-1α Degradation

The objective of our study was to examine the regulation of hypoxic expression of Hsp70 in nucleus pulposus cells and to determine if Hsp70 promoted HIF-1α degradation. Rat nucleus pulposus cells were maintained in culture in either 21% or 1% oxygen. To determine the regulation of Hsp70 expression b...

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Detalhes bibliográficos
Main Authors: Gogate, Shilpa S., Fujita, Nobuyuki, Skubutyte, Renata, Shapiro, Irving M, Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330204/
https://ncbi.nlm.nih.gov/pubmed/22322648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1571
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