COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells

The nucleus pulposus (NP) of intervertebral discs experiences dynamic changes in tissue osmolarity because of diurnal loading of the spine. TonEBP/NFAT5 is a transcription factor that is critical in osmoregulation as well as survival of NP cells in the hyperosmotic milieu. The goal of this study was...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Choi, Hyowon, Chaiyamongkol, Weera, Doolittle, Alexandra C., Johnson, Zariel I., Gogate, Shilpa S., Schoepflin, Zachary R., Shapiro, Irving M., Risbud, Makarand V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2018
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995512/
https://ncbi.nlm.nih.gov/pubmed/29700115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001167
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