TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

Intervertebral disc degeneration (IDD) causes chronic back pain and is linked to production of proinflammatory molecules by nucleus pulposus (NP) and other disc cells. Activation of tonicity-responsive enhancer-binding protein (TonEBP)/NFAT5 by non-osmotic stimuli, including proinflammatory molecule...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Johnson, Zariel I., Doolittle, Alexandra C., Snuggs, Joseph W., Shapiro, Irving M., Le Maitre, Christine L., Risbud, Makarand V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
Onderwerpen:
Gene Regulation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655530/
https://ncbi.nlm.nih.gov/pubmed/28842479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.790378
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