TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

Intervertebral disc degeneration (IDD) causes chronic back pain and is linked to production of proinflammatory molecules by nucleus pulposus (NP) and other disc cells. Activation of tonicity-responsive enhancer-binding protein (TonEBP)/NFAT5 by non-osmotic stimuli, including proinflammatory molecule...

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Udgivet i:J Biol Chem
Main Authors: Johnson, Zariel I., Doolittle, Alexandra C., Snuggs, Joseph W., Shapiro, Irving M., Le Maitre, Christine L., Risbud, Makarand V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655530/
https://ncbi.nlm.nih.gov/pubmed/28842479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.790378
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