Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and...

Por Le Maitre, Christine L, Hoyland, Judith A, Freemont, Anthony J
Publicado em 2007

A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration

Por Le Maitre, Christine L, Freemont, Anthony J, Hoyland, Judith A
Publicado em 2006

Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells

Por Le Maitre, Christine L, Freemont, Anthony J, Hoyland, Judith A
Publicado em 2009

An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue

Por Le Maitre, Christine L, Baird, Pauline, Freemont, Anthony J, Hoyland, Judith A
Publicado em 2009

Development of an in vitro model to test the efficacy of novel therapies for IVD degeneration

Por Le Maitre, Christine L., Fotheringham, Andrew P., Freemont, Anthony J., Hoyland, Judith A.
Publicado em 2009

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?

Por Thorpe, Abbey A., Binch, Abbie L.A., Creemers, Laura B., Sammon, Christopher, Le Maitre, Christine L.
Publicado no Oncotarget (2015)

Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies

Por Dunn, Sara L., Wilkinson, Jeremy Mark, Crawford, Aileen, Bunning, Rowena A.D., Le Maitre, Christine L.
Publicado no Cannabis Cannabinoid Res (2016)

TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

Por Johnson, Zariel I., Doolittle, Alexandra C., Snuggs, Joseph W., Shapiro, Irving M., Le Maitre, Christine L., Risbud, Makarand V.
Publicado no J Biol Chem (2017)

Investigation of intervertebral disc degeneration using multivariate FTIR spectroscopic imaging

Por Mader, Kerstin T., Peeters, Mirte, Detiger, Suzanne E. L., Helder, Marco N., Smit, Theo H., Le Maitre, Christine L., Sammon, Chris
Publicado no Faraday Discuss (2016)

Differential Effects of Polyphenols on Proliferation and Apoptosis in Human Myeloid and Lymphoid Leukemia Cell Lines

Por Mahbub, Amani A, Le Maitre, Christine L., Haywood-Small, Sarah L., McDougall, Gordon J., Cross, Neil A., Jordan-Mahy, Nicola
Publicado em 2013

Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration

Por LA Binch, Abbie, Cole, Ashley A, Breakwell, Lee M, Michael, Anthony LR, Chiverton, Neil, Cross, Alison K, Le Maitre, Christine L
Publicado em 2014

Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc

Por Binch, Abbie L. A., Cole, Ashley A., Breakwell, Lee M., Michael, Anthony L. R., Chiverton, Neil, Creemers, Laura B., Cross, Alison K., Le Maitre, Christine L.
Publicado no Oncotarget (2015)

Nerves are more abundant than blood vessels in the degenerate human intervertebral disc

Por Binch, Abbie L. A., Cole, Ashley A., Breakwell, Lee M., Michael, Antony L. R., Chiverton, Neil, Creemers, Laura B., Cross, Alison K., Le Maitre, Christine L.
Publicado no Arthritis Res Ther (2015)

The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc

Por Phillips, Kate L E, Chiverton, Neil, Michael, Anthony LR, Cole, Ashley A, Breakwell, Lee M, Haddock, Gail, Bunning, Rowena AD, Cross, Alison K, Le Maitre, Christine L
Publicado em 2013

TNF-α and IL-1β Dependent Induction of CCL3 Expression by Nucleus Pulposus Cells Promotes Macrophage Migration through CCR1

Por Wang, Jianru, Tian, Ye, Phillips, Kate L.E., Chiverton, Neil, Haddock, Gail, Bunning, Rowena A., Cross, Alison K., Shapiro, Irving M., LeMaitre, Christine L., Risbud, Makarand V.
Publicado em 2013

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells

Por Johnson, Zariel I., Gogate, Shilpa S., Day, Rebecca, Binch, Abbie, Markova, Dessislava Z., Chiverton, Neil, Cole, Ashley, Conner, Matt, Shapiro, Irving M., Le Maitre, Christine L., Risbud, Makarand V.
Publicado no Oncotarget (2015)

Molecular Mechanisms of Biological Aging in Intervertebral Discs

Por Vo, Nam V., Hartman, Robert A., Patil, Prashanti R., Risbud, Makarand V., Kletsas, Dimitris, Iatridis, James C., Hoyland, Judith A., Le Maitre, Christine L., Sowa, Gwendolyn A., Kang, James D.
Publicado no J Orthop Res (2016)

Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells: IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION

Por Wang, Hua, Tian, Ye, Wang, Jianru, Phillips, Kate L. E., Binch, Abbie L. A., Dunn, Sara, Cross, Alison, Chiverton, Neil, Zheng, Zhaomin, Shapiro, Irving M., Le Maitre, Christine L., Risbud, Makarand V.
Publicado em 2013

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

Por Steinberg, Julia, Ritchie, Graham R. S., Roumeliotis, Theodoros I., Jayasuriya, Raveen L., Clark, Matthew J., Brooks, Roger A., Binch, Abbie L. A., Shah, Karan M., Coyle, Rachael, Pardo, Mercedes, Le Maitre, Christine L., Ramos, Yolande F. M., Nelissen, Rob G. H. H., Meulenbelt, Ingrid, McCaskie, Andrew W., Choudhary, Jyoti S., Wilkinson, J. Mark, Zeggini, Eleftheria
Publicado no Sci Rep (2017)