Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells: IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION

The objective of the study was to investigate how inflammatory cytokines, IL-1β, and TNF-α control NOTCH signaling activity in nucleus pulposus (NP) cells. An increase in expression of selective NOTCH receptors (NOTCH1 and -2), ligand (JAGGED2), and target genes (HES1, HEY1, and HEY2) was observed i...

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Detalhes bibliográficos
Main Authors: Wang, Hua, Tian, Ye, Wang, Jianru, Phillips, Kate L. E., Binch, Abbie L. A., Dunn, Sara, Cross, Alison, Chiverton, Neil, Zheng, Zhaomin, Shapiro, Irving M., Le Maitre, Christine L., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675609/
https://ncbi.nlm.nih.gov/pubmed/23589286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446633
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