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TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

Elevated levels of TNF-α, IL-1β and a resultant increase in ADAMTS (a disintegrin-like and metalloprotease with thrombospondin type I motifs) expression is seen during disc degeneration. However, if these pro-inflammatory cytokines control ADAMTS activity is not definitively known. The goal of the i...

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Autors principals: Wang, Jianru, Markova, Dessislava, Anderson, D. Greg, Zheng, Zhaomin, Shapiro, Irving M., Risbud, Makarand V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220535/
https://ncbi.nlm.nih.gov/pubmed/21949132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264549
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