BMP-2 and TGF-β Stimulate Expression of β1,3-Glucuronosyl Transferase 1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP, and Sp1: Role of MAPKs

The goal of the study was to investigate bone morphogenetic protein 2 (BMP-2) and transforming growth factor β (TGF-β) control of the expression of β1,3-glucuronosyl transferase 1 (GlcAT-1), an important regulator of chondroitin sulfate synthesis in cells of the nucleus pulposus. Treatment with both...

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Detalhes bibliográficos
Main Authors: Hiyama, Akihiko, Gogate, Shilpa S, Gajghate, Sachin, Mochida, Joji, Shapiro, Irving M, Risbud, Makarand V
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153993/
https://ncbi.nlm.nih.gov/pubmed/19961337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.091202
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