Hypoxic Regulation of β1,3 Glucuronosyl Transferase-I (GlcAT-I) Expression in Nucleus Pulposus Cells of The Intervertebral Disc: Role of HIF Proteins

OBJECTIVE: The goal of the investigation was to study if hypoxia and HIF proteins regulate expression of GlcAT-I, a key enzyme in GAG synthesis in nucleus pulposus (NP) cells. METHODS: QRT-PCR and Western blot were used to measure GlcAT-I expression. Transfections were performed to determine the eff...

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Hlavní autoři: Gogate, Shilpa S., Nasser, Rena, Shapiro, Irving M., Risbud, Makarand V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125401/
https://ncbi.nlm.nih.gov/pubmed/21400481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30342
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