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Class I and IIa HDACs mediate HIF-1α stability through PHD2-dependent mechanism while HDAC6, a class IIb member, promotes HIF-1α transcriptional activity in nucleus pulposus cells of the intervertebral disc
The objective of this study was to determine the role of histone deacetylases (HDACs) in regulating HIF-1α protein stability and activity in nucleus pulposus (NP) cells. Treatment of NP cells with pan-HDAC inhibitor TSA resulted in decreased HIF-1α levels under both normoxia and hypoxia in a dose-de...
Gespeichert in:
| Veröffentlicht in: | J Bone Miner Res |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891304/ https://ncbi.nlm.nih.gov/pubmed/26765925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2787 |
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