HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells

Intervertebral disc degeneration is the leading cause of chronic back pain. Recent studies show that raised level of SDC4, a cell-surface heparan sulfate (HS) proteoglycan, plays a role in pathogenesis of disc degeneration. However, in nucleus pulposus (NP) cells of the healthy intervertebral disc,...

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Autors principals: Fujita, Nobuyuki, Hirose, Yuichiro, Tran, Cassie M., Chiba, Kazuhiro, Miyamoto, Takeshi, Toyama, Yoshiaki, Shapiro, Irving M., Risbud, Makarand V.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2014
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021441/
https://ncbi.nlm.nih.gov/pubmed/24558194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-243741
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