FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells

The objective of this study was to determine the role of FIH-1 in regulating HIF-1 activity in the nucleus pulposus (NP) cells and the control of this regulation by binding and sequestration of FIH-1 by Mint3. FIH-1 and Mint3 were both expressed in the NP and were shown to strongly co-localize withi...

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Bibliographic Details
Main Authors: Hirose, Yuichiro, Johnson, Zariel I., Schoepflin, Zachary R., Markova, Dessislava Z., Chiba, Kazuhiro, Toyama, Yoshiaki, Shapiro, Irving M., Risbud, Makarand V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110272/
https://ncbi.nlm.nih.gov/pubmed/24867948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565101
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