Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling

Recent studies suggest a differential role of prolyl hydroxylase (PHD) isoforms in controlling hypoxia-inducible factor (HIF)-α degradation and activity in nucleus pulposus (NP) cells. However, the regulation and function of PHDs under inflammatory conditions that characterize disc disease are not y...

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Detalhes bibliográficos
Main Authors: Fujita, Nobuyuki, Gogate, Shilpa S., Chiba, Kazuhiro, Toyama, Yoshiaki, Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501017/
https://ncbi.nlm.nih.gov/pubmed/22948157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.375964
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