Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus

Prolyl-4-hydroxylase (PHD) proteins are key in sensing tissue hypoxia. In nucleus pulposus (NP) cells, our previous work demonstrated that PHD isoforms have a differential contribution in controlling hypoxia-inducible factor (HIF)-α degradation and activity. Recently we have shown that a regulatory...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Li, Jun, Yuan, Wen, Jiang, Shuai, Ye, Wei, Yang, Hao, Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358139/
https://ncbi.nlm.nih.gov/pubmed/25635047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611483
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