HIF Regulation of ANK Expression in Nucleus Pulposus Cells: Possible Implications in Controlling Dystrophic Mineralization in the Intervertebral Disc

OBJECTIVE: Since nucleus pulposus cells reside in hypoxia, we determined if expression of ANK, a pyrophosphate transporter, is regulated by the HIF proteins. METHODS: Quantitative RT-PCR and Western blot were used to measure ANK expression in nucleus pulposus cells. Transfections were performed to d...

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Detalhes bibliográficos
Main Authors: Skubutyte, Renata, Markova, Dessislava, Freeman, Theresa A., Anderson, D. Greg, Dion, Arnold S., Williams, Charlene J., Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065237/
https://ncbi.nlm.nih.gov/pubmed/20496369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27558
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