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Hypoxia Activates the Notch Signaling Pathway in Cells of the Intervertebral Disc: Implications in Degenerative Disc Disease

OBJECTIVE: To investigate whether hypoxia regulates Notch signaling, and whether Notch plays a role in intervertebral disc cell proliferation. METHODS: Reverse transcription–polymerase chain reaction and Western blotting were used to measure expression of Notch signaling components in intervertebral...

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Bibliografiske detaljer
Main Authors: Hiyama, Akihiko, Skubutyte, Renata, Markova, Dessislava, Anderson, D. Greg, Yadla, Sanjay, Sakai, Daisuke, Mochida, Joji, Albert, Todd J., Shapiro, Irving M., Risbud, Makarand V.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613279/
https://ncbi.nlm.nih.gov/pubmed/21305512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30246
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