The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-X(L), Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

A critical hallmark of cancer cell survival is evasion of apoptosis. This is commonly due to overexpression of anti-apoptotic proteins such as Bcl-2, Bcl-X(L), and Mcl-1, which bind to the BH3 α-helical domain of pro-apoptotic proteins such as Bax, Bak, Bad, and Bim, and inhibit their function. We d...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Kazi, Aslamuzzaman, Sun, Jiazhi, Doi, Kenichiro, Sung, Shen-Shu, Takahashi, Yoshinori, Yin, Hang, Rodriguez, Johanna M., Becerril, Jorge, Berndt, Norbert, Hamilton, Andrew D., Wang, Hong-Gang, Sebti, Saïd M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2011
Θέματα:
Signal Transduction
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059047/
https://ncbi.nlm.nih.gov/pubmed/21148306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.203638
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