Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway through Processing of the EGF Precursor

Although the processing profile of the membrane-bound epidermal growth factor precursor (pro-EGF) is tissue-specific, it has not been investigated at the cellular level nor have the cognate proteinases been defined. Among the proprotein convertases (PCs), only the membrane-bound PC7, the most ancien...

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Bibliographic Details
Main Authors: Rousselet, Estelle, Benjannet, Suzanne, Marcinkiewicz, Edwidge, Asselin, Marie-Claude, Lazure, Claude, Seidah, Nabil G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059027/
https://ncbi.nlm.nih.gov/pubmed/21209099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189936
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