Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1: IDENTIFICATION OF SITES TARGETED FOR PHOSPHORYLATION AND UBIQUITINATION

Human liver CYP2E1 is a monotopic, endoplasmic reticulum-anchored cytochrome P450 responsible for the biotransformation of clinically relevant drugs, low molecular weight xenobiotics, carcinogens, and endogenous ketones. CYP2E1 substrate complexation converts it into a stable slow-turnover species d...

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Main Authors: Wang, YongQiang, Guan, Shenheng, Acharya, Poulomi, Koop, Dennis R., Liu, Yi, Liao, Mingxiang, Burlingame, Alma L., Correia, Maria Almira
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058980/
https://ncbi.nlm.nih.gov/pubmed/21209460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176685
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