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HEPATIC CYTOCHROME P450 UBIQUITINATION: CONFORMATIONAL PHOSPHODEGRONS FOR E2/E3 RECOGNITION?
Hepatic endoplasmic reticulum (ER) integral cytochromes P450 (P450s) are monooxygenases engaged in the biotransformation and elimination of endo- as well as xenobiotics. Of the human liver P450s, CYP3A4 is the major and most dominant catalyst, responsible for the biotransformation of over 50% of cli...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3959620/ https://ncbi.nlm.nih.gov/pubmed/24488826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iub.1247 |
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