A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation

Cytochromes P450 (P450s) incur phosphorylation. Although the precise role of this post-translational modification is unclear, marking P450s for degradation is plausible. Indeed, we have found that after structural inactivation, CYP3A4, the major human liver P450, and its rat orthologs are phosphoryl...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, YongQiang, Liao, Mingxiang, Hoe, Nicholas, Acharya, Poulomi, Deng, Changhui, Krutchinsky, Andrew N., Correia, Maria Almira
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Protein Synthesis, Post-Translational Modification, and Degradation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645824/
https://ncbi.nlm.nih.gov/pubmed/19095658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806104200
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