Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases: PHYSIOLOGICAL AND PHARMACOLOGICAL RELEVANCE

CYP3A4 is a dominant human liver cytochrome P450 enzyme engaged in the metabolism and disposition of >50% of clinically relevant drugs and held responsible for many adverse drug-drug interactions. CYP3A4 and its mammalian liver CYP3A orthologs are endoplasmic reticulum (ER)-anchored monotopic pro...

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Main Authors: Kim, Sung-Mi, Acharya, Poulomi, Engel, Juan C., Correia, Maria Almira
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975210/
https://ncbi.nlm.nih.gov/pubmed/20819951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167189
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