Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination: A PIVOTAL ROLE OF ITS SER-478 RESIDUE IN THE gp78-CATALYZED REACTION

CYP3A4, an integral endoplasmic reticulum (ER)-anchored protein, is the major human liver cytochrome P450 enzyme responsible for the disposition of over 50% of clinically relevant drugs. Alterations of its protein turnover can influence drug metabolism, drug-drug interactions, and the bioavailabilit...

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Detalhes bibliográficos
Main Authors: Wang, YongQiang, Guan, Shenheng, Acharya, Poulomi, Liu, Yi, Thirumaran, Ranjit K., Brandman, Relly, Schuetz, Erin G., Burlingame, Alma L., Correia, Maria Almira
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277751/
https://ncbi.nlm.nih.gov/pubmed/22101235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.010132
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