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Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP

Huntington's disease (HD) is caused by polyglutamine expansion in huntingtin (htt) protein, but the exact mechanism of HD pathogenesis remains uncertain. Recent evidence suggests that htt proteins with expanded polyglutamine tracts induce endoplasmic reticulum (ER) stress, probably by interferi...

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Detalhes bibliográficos
Main Authors: Yang, Hui, Liu, Chao, Zhong, Yongwang, Luo, Shouqing, Monteiro, Mervyn J., Fang, Shengyun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811200/
https://ncbi.nlm.nih.gov/pubmed/20126661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008905
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