Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD

Unwanted proteins in the endoplasmic reticulum (ER) are exported into the cytoplasm and degraded by the proteasome through the ER-associated protein degradation pathway (ERAD). Disturbances in ERAD are linked to ER stress, which has been implicated in the pathogenesis of several human diseases. Howe...

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Autors principals: Lim, Precious J., Danner, Rebecca, Liang, Jing, Doong, Howard, Harman, Christine, Srinivasan, Deepa, Rothenberg, Cara, Wang, Hongmin, Ye, Yihong, Fang, Shengyun, Monteiro, Mervyn J.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2009
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768832/
https://ncbi.nlm.nih.gov/pubmed/19822669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200903024
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