Leukotriene B(4) and its Metabolites Prime the Neutrophil Oxidase and Induce Pro-Inflammatory Activation of Human Pulmonary Microvascular Endothelial Cells

BACKGROUND: Leukotrienes are pro-inflammatory lipid mediators, derived from arachidonic acid via 5-lipoxygenase (5-LO). Leukotriene B(4) (LTB(4)) is an effective neutrophil (PMN) chemoattractant, as well as being a major product of PMN priming. LTB(4) is rapidly metabolized into products that are th...

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Detalhes bibliográficos
Main Authors: Eun, John C., Moore, Ernest E., Banerjee, Anirban, Kelher, Marguerite R., Khan, Samina Y., Elzi, David J., McLaughlin, Nathan J.D., Silliman, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056395/
https://ncbi.nlm.nih.gov/pubmed/20926984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e3181faceb3
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