Supernatants and Lipids from Stored RBCs Activate Pulmonary Microvascular Endothelium through the BLT2 Receptor and Protein Kinase C Activation

BACKGROUND: Although transfusion is a life-saving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored red blood cells induce pro-inflammatory activation of human pulmonary microvascular endothelium (HMVECs) resulting in neutrophil (PMN) adhes...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., West, F. Bernadette, McLaughlin, Nathan J. D., Elzi, David J., England, Kelly J., Bjornsen, Jason, Kuldanek, Susan A., Banerjee, Anirban
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775889/
https://ncbi.nlm.nih.gov/pubmed/28880373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.14271
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