LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47(phox) phosphorylation and membrane translocation in neutrophils

Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury (TRALI). LysoPCs cause ligation of the G2A receptor, cytosolic Ca(2+) flux, and activation of Hck. We hypothesize that lysoPCs induce Hck-dependent a...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Kelher, Marguerite R., McLaughlin, Nathan J. D., Banerjee, Anirban, Elzi, David J., Gamboni, Fabia, Khan, Samina Y., Meng, Xianzhong, Mitra, Sanchayita, Silliman, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2017
Assuntos:
Inflammation, Extracellular Mediators, & Effector Molecules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166440/
https://ncbi.nlm.nih.gov/pubmed/27531930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0813-420RRR
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