Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67(phox) and p40(phox) That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils

Neutrophils (polymorphonuclear leukocytes, PMNs) are vital to innate immunity and receive proinflammatory signals that activate G protein-coupled receptors (GPCRs). Because GPCRs transduce signals through clathrin-mediated endocytosis (CME), we hypothesized that platelet-activating factor (PAF), an...

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Autori principali: McLaughlin, Nathan J. D., Banerjee, Anirban, Khan, Samina Y., Lieber, Janet L., Kelher, Marguerite R., Gamboni-Robertson, Fabia, Sheppard, Forest R., Moore, Ernest E., Mierau, Gary W., Elzi, David J., Silliman, Christopher C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065328/
https://ncbi.nlm.nih.gov/pubmed/18523285
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