α-enolase Causes Pro-Inflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils through Plasmin Activation of Protease-Activated Receptor-2

Pro-inflammatory activation of vascular endothelium leading to increased surface expression of adhesion molecules and neutrophil (PMN) sequestration and subsequent activation is paramount in the development of acute lung (ALI) and organ injury in injured patients. We hypothesize that α-enolase, whic...

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Détails bibliographiques
Publié dans:Shock
Auteurs principaux: Bock, Ashley, Tucker, Nicole, Kelher, Marguerite R., Khan, Samina Y., Gonzalez, Eduardo, Wohlauer, Max, Hansen, Kirk, Dzieciatkowska, Monika, Sauaia, Angels, Banerjee, Anirban, Moore, Ernest E., Silliman, Christopher C.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506257/
https://ncbi.nlm.nih.gov/pubmed/25944790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000394
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