Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C–terminal residues of PKA

Lignende værker

• The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
  af: Biondi, Ricardo M., et al.
  Udgivet: (2001)
• In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation
  af: Collins, Barry J., et al.
  Udgivet: (2003)
• The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1
  af: Xu, Xinyuan, et al.
  Udgivet: (2019)
• A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
  af: Frödin, Morten, et al.
  Udgivet: (2002)
• High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
  af: Biondi, Ricardo M., et al.
  Udgivet: (2002)