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The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1
Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target. The catalytic activity of PDK1 is tightly regulated by allosteric modulators, which bind to the PDK1 Interacting Fragment (PIF) pocket of the kin...
Guardat en:
| Publicat a: | J Enzyme Inhib Med Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6327997/ https://ncbi.nlm.nih.gov/pubmed/30734603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1553167 |
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