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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C–terminal residues of PKA
The 3-phosphoinositide-dependent protein kinase–1 (PDK1) phosphorylates and activates a number of protein kinases of the AGC subfamily. The kinase domain of PDK1 interacts with a region of protein kinase C–related kinase–2 (PRK2), termed the PDK1-interacting fragment (PIF), through a hydrophobic mot...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305637/ https://ncbi.nlm.nih.gov/pubmed/10698939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.5.979 |
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